Taking this item DOES count as a devil deal, preventing future angel rooms. These stack with multiple secret rooms - The first one gives +1.00 Tears Up, then all future ones give +0.5. Unlocked from Challenge #24 - PAY TO PLAY, Friends till the end - Spawns three friendly blue attack flies, Infested! Item Pool: Item Room, Secret Room, Crane Game, Taking damage for the first time in a room spawns a familiar which targets an enemy and jumps on them, releasing a rock wave outwards, For the remainder of the room the familiar then continues to attack enemies similar to the Dead Bird item dealing 3 contact damage per tick. Larry Jr.) it will split them into 2 smaller enemies with half the number of sections they used to have, If the enemy normally has a mechanic that splits it (e.g. If you have 1 or less heart containers, this pill becomes Health Up, Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor. shop room pool, shop item pool, cross, brown, Upon use, gives +2 damage up which lasts for the current room, x1.5 times Damage Multiplier if you also have Blood of the Martyr (Does not stack with Magic Mushroom or Cricket's Head multipliers), Increases your chances of getting a devil/angel room by +12.5%, REPENTANCE - The effect stacks if used multiple times, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, starting Hook Worm, Wiggle Worm etc. Poison) rapidly due to how often it hits, REPENTANCE - The -65% Damage down has been removed! It returns after a room has been cleared, UNLOCK: Unlock this item by beating Greed Mode with Eden, Item Pool: Item Room, Secret Room, Greed Mode Shop, *, red, yellow, green, white, square, rectangle, When used, the D8 rerolls all of your stats, Will only effect your damage, tears, range and speed stats, Each stat is given a multiplier that applies after all other adjustments, UNLOCK: Unlock this item by beating Challenge #28 (Pride Day), * dice, pip, die, black, grey, gray, pyramid, triangle, Purity will boost one of Isaac's stats depending on the colour of the aura around him, When you take damage, the aura will be removed and replaced with another random one when you enter the next room, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Maggy, Item Pool: Item Room, Angel Room, Greed Mode Item Room, Greed Mode Angel Room, Adds a chance for a black ring to spawn around killed enemies, dealing damage to others that touch it, The ring damage scales with your tear damage, The change for a ring to spawn scales with your lucky stat, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eve, Item Pool: Devil Room, Curse Room, Greed Mode Devil Room, *, grey, gray, silver, metal grabber, hand, robot, When Isaac has no red hearts, this item gives Isaac the ability to fly. Midnight Snack = +1 flat damage, +1 luck. This is a one-time use of the Red Key item. Based on the Steam Workshop mod created by Amethyst, UNLOCK: Unlock this item by using 5 Gulp! Blood Bag) it will be rerolled into a random Item Room item, Cannot remove Azazel's Brimstone laser, or The Lost's Holy Mantle, REPENTANCE - Full run reroll effects are now able to remove heart containers and transformations if losing the respective items during the reroll, UNLOCK: Unlock this item by blowing up 30 slot machines, * item room, treasure room, item room pool, dice pip, starting, pyramid, green, triange, When used, 'devolves' all enemies in the room which are currently alive into another weaker type of enemy, * item room, treasure room, item room pool, DIO, dice pip, orange, brown, turban, When used, copies the effect of the card you are currently holding without consuming it, The charge time of this item depends on the quality of the card you're holding, Using this with the ? Cursed gives a card that buys everything in a shop for free (or devil room) Waka Waka and the Host unlock some great items (scythe tears, and added laser to your tears without harming normal tears) Family Man unlocks epic fetus, which is way overpowered. REPENTANCE - This item was completely reworked for Repentance and no longer forces a random dice use each time. This means you need a way to teleport out of the Mom's Foot boss fight. Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation. It can spawn familiars you haven't unlocked yet! Item Pool: Angel Room *, Sol. With +0.5 Damage being one of the possible random stat rewards, this item is really the only Damage Up you'll need for the entire run. 9 Prayer Card. Every so often it will come up and attempt to grab onto a random enemy in the room, holding them in place and dealing damage, The Worm Friend deals 4 damage for 8 ticks total, If the enemy moves quickly enough it can miss its attack, UNLOCK: Unlock this item by defeating The Beast as Apollyon, Enemies that die will leave behind 1-2 floating bone shards where they die, until you leave the room, Other enemies that touch the bone shards will take 3.5 damage, with a chance to either bounce off them or cause it to break and disappear, UNLOCK: Unlock this item by defeating Mother as The Forgotten, Each time an enemy dies, a friendly red soul appears. Any item that unlocks Red Rooms is also a good one to prioritize for this reason, such as Soul of Cain (Boss Rush and Hush as Tainted Cain), Crystal Key (Mother as Tainted Lost), and Reverse Moon (Greedier as Tainted Jacob). The recharge time of this item depends on the Rune/Soul Stone held: 2 rooms: Rune of Ansuz, Rune of Berkano, Rune of Hagalaz, Soul of Cain, 3 rooms: Rune of Algiz, Blank Rune, Soul of Magdalene, Soul of Judas, Soul of ?? sack, pouch, blue, purple, Tears gain a damage up and increase in size based on the distance they travel, The length of a normal room roughly gives +6 damage, but this can be higher with double rooms or Tiny Planet, This item synergises with beam items such as Brimstone and Tech, allowing them to do more damage the further away the enemy is, When used, removes one heart container and gives you 3 soul hearts, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, ?, Satan and The Lamb as Tainted Cain, Spawns a sack at the start of each new floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Cain, Causes an Item Room and Shop to appear in Sheol, UNLOCK: Unlock this trinket by defeating Isaac, ?? This is decided by whatever you have the least of. - Tears will shoot diagonally for about 60 seconds. Counts as 1 of 3 spider items needed towards the Spider Baby transformation. Once you beat her, you'll unlock Jacob & Esau. FRA1DN0T. Tears are now white, do a lot more damage and move slower across the screen with a homing effect, * angel room pool, god room pool, angel room item, red, fire, flame, orange, cross, Does not increase your damage, simply makes your tears red, * boss room pool, boss room item, sticks, brown, yellow, * angel room pool, god room pool, angel room item, the lost item pool, cup, wooden, gold, Pressing the bomb button will put the next poop into the 'Hold' jar. ?s only friend, blue bozzy, An iron ball and chain attached to Isaac, similar to Guppy's Hairball that you can fling around to deal 5 damage per tick, The ball will block enemy shots and can also destroy environmental objects such as rocks, mushrooms and skulls, Does not decrease your movement speed stat at all however the ball has to be dragged around causing Isaac to slow down slightly when the chain is fully extended, UNLOCK: Unlock this item by beating Boss Rush with Samson, * secret room pool, item room, treasure room, item room pool, grey, gray, shackle, A familiar that will follow Isaac and copy the effect of one of your other familiars, If you don't have any other familiars, he will just shoot normal tears, REPENTANCE - Removed the double damage multiplier on Mongo Baby's attacks, * item room, treasure room, item room pool, pink, blue, grey, gray, An active item that fires 8 of Isaac's tears in a circle around him, Tears spawned from this item keep most effect that Isaac currently has applied to his tears, and deal an additional +5 flat damage, UNLOCK: Unlock this item by beating the Isaac boss with Isaac, * item room, treasure room, item room pool, glass, blue, water, isaacs tears, Upon use, teleports you to one of the following rooms at random: Item room, Secret room, Super secret room, the I AM ERROR room or the Black Market (very low chance), There are no I AM ERROR rooms on the final floors, preventing looping with this item, UNLOCK: Unlock this item by beating Boss Rush with Eden, * item room, treasure room, item room pool, pink, purple, red, broken, When used will cut your head from your body. To unlock Eve simply beat two floors in a row without picking up hearts. (Blue baby), *, dead, blue, face, fates reward, fate reward, A familiar chest that follows Isaac and has a 25% chance to drop a pickup after clearing a room, Possible drops include hearts, coins, bombs, key, pills, card, runes, batteries, trinket, UNLOCK: Unlock this item by beating Greed Mode with Isaac, Item Pool: Item Room, Greed Mode Item Room, Beggar, An orbital angel which does 7 contact damage per tick and blocks shots, The angel will attract bullets towards it and block them, Sworn Protector will drop an eternal heart if it blocks 10 shots in one room. If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. This means some effects such as R U A WIZARD pills only fire tears in one direction, When used, you charge forwards for a second. The only way to remove it is via having a second trinket slot (Mom's Purse, Belly Button) or absorbing it (Marbles, Smelter, Gulp! While aggressive, Blood Puppy deals 7.5 damage and drops half a red heart for every 10 enemies it kills. The mirrored floor rooms have respawned enemies, and allows you to optionally fight the Boss a second time for an extra item, When combined with Knife Piece 2, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, Combine with Knife Piece 1 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Mines/Ashpit II, there's a room with a minecart and a broken track. Use the key to stab the door open and you'll head down to Corpse. Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost', If held when you touch the chest after the Satan or Isaac fight and you don't have the relevant item to go to the next floor (Polaroid or Negative), you have a small chance to be taken there anyway, UNLOCK: Unlock this item by beating the Chest with Eden, 80% of heart drops are replaced with keys, Hearts turn into black hearts where possible. REPENTANCE - Dark Prince's Crown now grants more of an increase in rate of fire, and the bonus now breaks the soft tears cap. You still take damage however when using Blood Donation machines and Devil Beggars, *, spikes, spikey, spike rock, greyhost, grey host, Causes all pedestal items to show up as rotating items, that swap every 1 second between the original spawned item and a HP up item. Releasing Dark Esau will cause him to charge directly at Jacob and deal damage to anything in his path. Deals 45 damage to enemies it lands on. Glitched Crown is in this list as the strongest among them once you learn how to pick out the item you want consistently. UNLOCK: Unlock this item by beating Greed Mode with ??? When used, it retrieves the Forgotten skull, causing it to shoot back into your arms, Tainted Bethany - Spawns four random item wisps of high quality with significantly higher HP than normal, Tainted Jacob - Dark Esau splits into 2. the lost item pool, gold, orange, yellow, cross, pope, hat, A familiar the follows Isaac and fires random tears, Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc, * item room, treasure room, item room pool, purple, Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors, Can be used to open the golden door that appears in the Dark Room or the Chest, Cannot be used to escape the Mom's Foot boss, open angel/devil rooms, or open the door to the Blue Womb floor, UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. The beams of light now trail behind Isaac when charging with it (damage formula of the beams is damage * 4 + 10). Related: How to unlock Downpour in Binding of Isaac Repentance. While playing as him Anima Sola will always target Dark Esau. Fortune Cookie is good because of the low cost compared to other items like Crystal Ball. However, If you also have flying you will always take damage, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, circle, bomb, A random chance when you take damage to get an invincibility shield for 7 seconds, The chance to get an invincibility shield is affected by your luck stat and at +10 Luck it will activate every time you get hit, Converts all negative pills into their positive counterparts e.g. Both charge at the same time and using Anima Sola chains both in the same spot, Significantly increases damage by +21.6, however the damage boost wears off slowly over time at a rate of roughly -0.04 per second, Every enemy you kill adds +0.02 Damage to the timed effect of Red Stew, UNLOCK: Unlock this item by defeating Satan as Jacob & Esau, When used, removes all your passive items and teleports you to Isaac's Bedroom, For every passive item removed, you are given a choice of 3 random pedestal items from any item pool. The Binding of Isaac: Repentance . Void tears that touch enemies will spawn Big Horn, who appears and grabs them, instantly killing that enemy, The chance to for each tear to become a void tear is affected by your luck stat and at +15 Luck it will activate 20% of the time, Isaac also grows a horn on his head, which causes you to deal contact damage to enemies by running into them (this effect deals base damage of 3.5 per tick), Void tears from this item can also destroy blue/purple fires, spiked blocks and stone grimaces, When used, will spawn a fly turret that doesn't move and fires tears at nearby enemies, The fly's bullets deal 3.5 damage each and do not scale with your own damage stat. Want to play with item revealing mods and still unlock unlocks. Gives a small chance when entering a room for enemies to be petrified for 4 seconds. Unlike the regular D6, rerolled items can pick from any item pool, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Eden, When used, Isaac dies and becomes The Lost for the current room. This item is also extra strong in Ascension runs and Greed Mode runs. Unfortunately, some of these unlocks are obtainable while beating Mother and currently on PS4, it does happen that the game will crash while entering the fight. Isaac takes a full heart if hurt by Blood Puppy and it drops a full red heart for every 10 enemies it kills. Mulligan can be hit by enemy projectiles, making him a good shield, Enemies will sometimes target the Mulligan if he is closer, * item room, treasure room, item room pool, sad, baby, lumpy, brown, pink, When used, makes Isaac leap in the air, similar to the leaper enemies, Maintains momentum if you are already moving in the same direction, If you already have an item which gives you flying, this item becomes a dash effect instead, Can be used in the Isaac boss fight to jump over the beams of light he spawns, * library pool, library room, book room pool, item room, treasure room, item room pool, And then you have the T. Lost mega satan unlock. 0 share; Share; How to create custom challenges in the Binding of Isaac. The Red Key item is required to access it, but it shows the direction to get there, UNLOCK: Unlock this item by defeating The Beast as Eve, Upon entering each new floor, if you have one red heart or less, another one is added, This effect works while moving up floors in the backwards path, This item has no effect for characters with non-red health i.e. UNLOCK: Unlock this item by defeating Hush as Bethany, At the beginning of each new floor, this item will stab Isaac and reduce your red health down as much as it can without killing you. ?, Satan and The Lamb as Tainted Isaac, Every time you enter a brand new room, you have a chance to get a random one-time use Dice (e.g. It can be anything including spawning a bunch of consumables, spawning a glitched pedestal item, creating a bunch of light beams, spawning troll bombs or nothing at all, UNLOCK: Unlock this item by defeating The Beast as Eden, "Isaac and his mother lived alone in a small house on a hill", When picked up, all future items become 'glitched', causing them to become random combinations of 2-3 effects based on other items, Glitched items can be passive or active and are completely randomly generated with infinite possibilities (similar to other 'Randomizer' games), The ratio of active to passive item effects given is 1/4, Random effects combine effects that exist on other items, and assign them to a random event (e.g. Here i will tell you how to unlock all of the new reverse tarot cards, that came with the release of the new DLC repentance. 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